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Neonatal Drug Withdrawal

MedGen UID:
761916
Concept ID:
C3540839
Mental or Behavioral Dysfunction

Definition

A constellation of neurobehavioral features observed following cessation or reduction of antenatal or postnatal drug exposure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Drug Withdrawal

Professional guidelines

PubMed

Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Bio LL, Siu A, Poon CY
J Perinatol 2011 Nov;31(11):692-701. Epub 2011 Aug 25 doi: 10.1038/jp.2011.116. PMID: 21869765
Alderman EM, Schonberg SK, Cohen MI
Pediatr Rev 1992 Aug;13(8):314-8. doi: 10.1542/pir.13-8-314. PMID: 1437897

Recent clinical studies

Etiology

Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
Pryor JR, Maalouf FI, Krans EE, Schumacher RE, Cooper WO, Patrick SW
Arch Dis Child Fetal Neonatal Ed 2017 Mar;102(2):F183-F187. Epub 2017 Jan 10 doi: 10.1136/archdischild-2015-310045. PMID: 28073819Free PMC Article
Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO
Pediatrics 2015 May;135(5):842-50. Epub 2015 Apr 13 doi: 10.1542/peds.2014-3299. PMID: 25869370Free PMC Article
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Bio LL, Siu A, Poon CY
J Perinatol 2011 Nov;31(11):692-701. Epub 2011 Aug 25 doi: 10.1038/jp.2011.116. PMID: 21869765

Diagnosis

Engelhardt KA, Liebow J, Fofah O, Khokhar A, Velazquez DM
Clin Pediatr (Phila) 2023 Mar;62(3):184-187. Epub 2022 Aug 22 doi: 10.1177/00099228221119663. PMID: 35996320
Vo QT, Thompson DF
Ann Pharmacother 2019 May;53(5):523-536. Epub 2018 Dec 10 doi: 10.1177/1060028018819450. PMID: 30525921
Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
Barthell JE, Mrozek JD
Minn Med 2013 Mar;96(3):48-50. PMID: 23930471
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123

Therapy

Engelhardt KA, Liebow J, Fofah O, Khokhar A, Velazquez DM
Clin Pediatr (Phila) 2023 Mar;62(3):184-187. Epub 2022 Aug 22 doi: 10.1177/00099228221119663. PMID: 35996320
Vo QT, Thompson DF
Ann Pharmacother 2019 May;53(5):523-536. Epub 2018 Dec 10 doi: 10.1177/1060028018819450. PMID: 30525921
Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Pediatrics 1983 Dec;72(6):895-902. PMID: 6139783

Prognosis

Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO
Pediatrics 2015 May;135(5):842-50. Epub 2015 Apr 13 doi: 10.1542/peds.2014-3299. PMID: 25869370Free PMC Article
Shephard R, Greenough A, Johnson K, Gerada C
Acta Paediatr 2002;91(9):951-3. doi: 10.1080/080352502760272641. PMID: 12412871
Pediatrics 1998 Jun;101(6):1079-88. PMID: 9614425

Clinical prediction guides

Timpson W, Killoran C, Maranda L, Picarillo A, Bloch-Salisbury E
Adv Neonatal Care 2018 Feb;18(1):70-78. doi: 10.1097/ANC.0000000000000441. PMID: 29045256Free PMC Article
Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
Pryor JR, Maalouf FI, Krans EE, Schumacher RE, Cooper WO, Patrick SW
Arch Dis Child Fetal Neonatal Ed 2017 Mar;102(2):F183-F187. Epub 2017 Jan 10 doi: 10.1136/archdischild-2015-310045. PMID: 28073819Free PMC Article
Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO
Pediatrics 2015 May;135(5):842-50. Epub 2015 Apr 13 doi: 10.1542/peds.2014-3299. PMID: 25869370Free PMC Article
Shephard R, Greenough A, Johnson K, Gerada C
Acta Paediatr 2002;91(9):951-3. doi: 10.1080/080352502760272641. PMID: 12412871

Recent systematic reviews

Bruzelius E, Underhill K, Askari MS, Kajeepeta S, Bates L, Prins SJ, Jarlenski M, Martins SS
Int J Drug Policy 2024 Apr;126:104380. Epub 2024 Mar 14 doi: 10.1016/j.drugpo.2024.104380. PMID: 38484529Free PMC Article

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